Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate vasodilation under hypoxia.

The systemic response to decreasing oxygen levels is hypoxic vasodilation. While this mechanism has been known for more than a century, the underlying cellular events have remained incompletely understood. Nitrite signaling is critically involved in vessel relaxation under hypoxia. This can be attri...

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Bibliographic Details
Main Authors: Matthias Totzeck, Ulrike B Hendgen-Cotta, Malte Kelm, Tienush Rassaf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4141839?pdf=render