Microenvironment-dependent phenotypic changes in a SCID mouse model for malignant mesothelioma

Microenvironment-dependent phenotypic changes in a SCID mouse model for malignant mesothelioma

Background and Aims: Malignant mesothelioma is an aggressive, therapy-resistant tumor. Mesothelioma cells may assume an epithelioid or a sarcomatoid phenotype, and presence of sarcomatoid cells predicts poor prognosis. In this study, we investigated differentiation of mesothelioma cells in a xenogra...

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Bibliographic Details
Main Authors: Eva eDarai-Ramqvist, Gustav eNilsonne, Carmen eFlores-Staino, Anders eHjerpe, Katalin eDobra
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Oncology
Subjects:
Mesothelioma
differentiation
SCID mice
epithelioid
sarcomatoid
chromosome 3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00203/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00203/full

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