Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Abstract Background Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular levels of endoplasmic reticulum (ER) resident chaperones such as Kar2...

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Bibliographic Details
Main Authors: Gustavo Roth, Ana Letícia Vanz, Heinrich Lünsdorf, Manfred Nimtz, Ursula Rinas
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Microbial Cell Factories
Subjects:
Autophagy
Kar2/Bip
Pichia pastoris
Unfolded protein response
Online Access:http://link.springer.com/article/10.1186/s12934-018-0970-3

Internet

http://link.springer.com/article/10.1186/s12934-018-0970-3

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