TALEN-mediated biallelic inactivation of MYB in human embryonic stem cell lines WAe001-A-45 and WAe001-A-46

TALEN-mediated biallelic inactivation of MYB in human embryonic stem cell lines WAe001-A-45 and WAe001-A-46

MYB/c-MYB is a proto-oncogene encoding a helix-turn-helix transcription factor that plays a critical role in controlling proliferation and multilineage differentiation of hematopoietic progenitor and stem cells. Deregulation of MYB expression is associated with several types of leukemias and lymphom...

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Bibliographic Details
Main Authors: Chenyu Fan, Zahir Shah, Hanif Ullah, Elena S. Philonenko, Baoyun Zhang, Ying Tan, Cuihua Wang, Jianguang Zhang, Igor M. Samokhvalov
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Stem Cell Research
Subjects:
MYB
Gene targeting
TALEN
hESCs
in vitro differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120301550

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http://www.sciencedirect.com/science/article/pii/S1873506120301550

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