High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

Aim: Sirtuins are NAD+-dependent deacetylases that regulate cell metabolism through protein acetylation/deacetylation, and SIRT3 is the major deacetylase among mitochondrial isoforms. Here, we elucidated the possible role of acetylation of cyclophilin D, a key regulator of the mitochondrial permeabi...

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Bibliographic Details
Main Authors: Rebecca M. Parodi-Rullán, Xavier Chapa-Dubocq, Pedro J. Rullán, Sehwan Jang, Sabzali Javadov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
heart
mitochondria
SIRT3
ischemia-reperfusion
sanglifehrin A
protein acetylation
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00275/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00275/full

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