Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor

Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor

The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine offers promising perspectives for the treatment of major depressive disorder. Although ketamine demonstrates rapid and long-lasting effects, even in treatment-resistant patients, to date, the underlying mode of action remains elusive. Thus...

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Bibliographic Details
Main Authors: Alessandra Grossert, Narges Zare Mehrjardi, Sarah J. Bailey, Mark A. Lindsay, Jürgen Hescheler, Tomo Šarić, Nicole Teusch
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
human iPSC-derived NPCs
depression
neurogenesis
ketamine
IGF2
cAMP
p11
Online Access:https://www.mdpi.com/2073-4409/8/10/1139

Internet

https://www.mdpi.com/2073-4409/8/10/1139

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