Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition

This study aimed to investigate the high glucose damage on human retinal pigment epithelial (RPE) cells, the role of p38 MAPK signaling pathway and how dimethyl fumarate can regulate that. We carried out in vitro studies on ARPE-19 cells exposed to physiological and high glucose (HG) conditions, to...

Full description

Bibliographic Details
Main Authors: Grazia Maugeri, Claudio Bucolo, Filippo Drago, Settimio Rossi, Michelino Di Rosa, Rosa Imbesi, Velia D’Agata, Salvatore Giunta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
retinal pigment epithelial cells
diabetic retinopathy
VEGF
dimethyl fumarate
p38 MAPK
retina
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.684680/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.684680/full

Similar Items