Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Abstract Background We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immu...

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Bibliographic Details
Main Authors: Cherry S. Leung, Kevin Y. Yang, Xisheng Li, Vicken W. Chan, Manching Ku, Herman Waldmann, Shohei Hori, Jason C. H. Tsang, Yuk Ming Dennis Lo, Kathy O. Lui
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Medicine
Subjects:
Single-cell transcriptomics
Transplant tolerance
CD4+ regulatory T cells
PD-1
Human pancreatic beta cells
Online Access:http://link.springer.com/article/10.1186/s13073-018-0581-y

Internet

http://link.springer.com/article/10.1186/s13073-018-0581-y

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