Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum

Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum

Patients with chronic kidney disease (CKD) have a markedly increased incidence of cardiovascular disease (CVD). The high concentration of circulating uremic toxins and alterations in mineral metabolism and hormone levels produce vascular wall remodeling and significant vascular damage. Medial calcif...

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Bibliographic Details
Main Authors: Violeta Cazaña-Pérez, Pilar Cidad, Javier Donate-Correa, Ernesto Martín-Núñez, José R. López-López, M. Teresa Pérez-García, Teresa Giraldez, Juan F. Navarro-González, Diego Alvarez de la Rosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Physiology
Subjects:
vascular calcification
uremia
chronic kidney disease
apoptosis
osteogenic differentiation
uremic serum
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00089/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00089/full

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