Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

Abstract Background Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable sensitivity to nsp14-ExoN deficiency. Betacoronavirus murine hepatitis vi...

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Bibliographic Details
Main Authors: Xiaoyu Niu, Fanzhi Kong, Yixuan J. Hou, Qiuhong Wang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cell & Bioscience
Subjects:
Porcine epidemic diarrhea virus
Coronavirus
Nsp14
Exoribonuclease
Reverse genetics
Infectious clone
Online Access:https://doi.org/10.1186/s13578-021-00598-1

Internet

https://doi.org/10.1186/s13578-021-00598-1

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