Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion.
Forward genetic screens have been used as a powerful strategy to dissect complex biological pathways in many model systems. A significant limitation of this approach has been the time-consuming and costly process of positional cloning and molecular characterization of the mutations isolated in these...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-07-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1183521?pdf=render |