Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Abstract Genome-wide expression profiling studies have identified four core molecular subgroups of medulloblastoma: WNT, SHH, Group 3 and Group 4. Molecular markers are necessary for accurate risk stratification in the non-WNT subgroups due to the underlying heterogeneity in genetic alterations and...

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Main Authors: Harish Shrikrishna Bharambe, Raikamal Paul, Pooja Panwalkar, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, Sadaf Kazi, Akash Deogharkar, Shalaka Masurkar, Kedar Yogi, Ratika Kunder, Nikhil Gadewal, Atul Goel, Naina Goel, Girish Chinnaswamy, Vijay Ramaswamy, Neelam Vishwanath Shirsat
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
Medulloblastoma
MiR-204
Risk stratification
Tumor-suppression
Autophagy
Online Access:http://link.springer.com/article/10.1186/s40478-019-0697-3

Internet

http://link.springer.com/article/10.1186/s40478-019-0697-3

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