Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing.

Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing.

Target-based screening is one of the major approaches in drug discovery. Besides the intended target, unexpected drug off-target interactions often occur, and many of them have not been recognized and characterized. The off-target interactions can be responsible for either therapeutic or side effect...

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Bibliographic Details
Main Authors: Hansaim Lim, Aleksandar Poleksic, Yuan Yao, Hanghang Tong, Di He, Luke Zhuang, Patrick Meng, Lei Xie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5055357?pdf=render

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http://europepmc.org/articles/PMC5055357?pdf=render

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