Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer

Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45<sup>+</sup> immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (...

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Bibliographic Details
Main Authors: Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L. R. Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G. Gorenstein, David E. Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
e-selectin
aptamer
doxorubicin
tumor-associated-macrophages
Online Access:https://www.mdpi.com/2072-6694/12/3/725

Internet

https://www.mdpi.com/2072-6694/12/3/725

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