Thermal Activation of Thin Filaments in Striated Muscle

In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on–off” equilibrium of the thin filament state toward the “on” sate, promoting actomyosin interaction. Likewise, recent stu...

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Main Authors:	Shuya Ishii, Kotaro Oyama, Seine A. Shintani, Fuyu Kobirumaki-Shimozawa, Shin’ichi Ishiwata, Norio Fukuda
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Series:	Frontiers in Physiology
Subjects:	actomyosin Ca2+ sensitivity cardiac muscle skeletal muscle temperature tropomyosin
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2020.00278/full

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spelling	doaj-af03d3ade3ad4d5594389b6900fdefbd2020-11-25T02:28:43ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-04-011110.3389/fphys.2020.00278527402Thermal Activation of Thin Filaments in Striated MuscleShuya Ishii0Shuya Ishii1Kotaro Oyama2Kotaro Oyama3Seine A. Shintani4Fuyu Kobirumaki-Shimozawa5Shin’ichi Ishiwata6Norio Fukuda7Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, JapanQuantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, Gunma, JapanQuantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, Gunma, JapanPRESTO, Japan Science and Technology Agency, Saitama, JapanDepartment of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, JapanDepartment of Cell Physiology, The Jikei University School of Medicine, Tokyo, JapanDepartment of Physics, Faculty of Science and Engineering, Waseda University, Tokyo, JapanDepartment of Cell Physiology, The Jikei University School of Medicine, Tokyo, JapanIn skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on–off” equilibrium of the thin filament state toward the “on” sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; viz., an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the “on–off” equilibrium of the thin filament state.https://www.frontiersin.org/article/10.3389/fphys.2020.00278/fullactomyosinCa2+ sensitivitycardiac muscleskeletal muscletemperaturetropomyosin
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shuya Ishii Shuya Ishii Kotaro Oyama Kotaro Oyama Seine A. Shintani Fuyu Kobirumaki-Shimozawa Shin’ichi Ishiwata Norio Fukuda
spellingShingle	Shuya Ishii Shuya Ishii Kotaro Oyama Kotaro Oyama Seine A. Shintani Fuyu Kobirumaki-Shimozawa Shin’ichi Ishiwata Norio Fukuda Thermal Activation of Thin Filaments in Striated Muscle Frontiers in Physiology actomyosin Ca2+ sensitivity cardiac muscle skeletal muscle temperature tropomyosin
author_facet	Shuya Ishii Shuya Ishii Kotaro Oyama Kotaro Oyama Seine A. Shintani Fuyu Kobirumaki-Shimozawa Shin’ichi Ishiwata Norio Fukuda
author_sort	Shuya Ishii
title	Thermal Activation of Thin Filaments in Striated Muscle
title_short	Thermal Activation of Thin Filaments in Striated Muscle
title_full	Thermal Activation of Thin Filaments in Striated Muscle
title_fullStr	Thermal Activation of Thin Filaments in Striated Muscle
title_full_unstemmed	Thermal Activation of Thin Filaments in Striated Muscle
title_sort	thermal activation of thin filaments in striated muscle
publisher	Frontiers Media S.A.
series	Frontiers in Physiology
issn	1664-042X
publishDate	2020-04-01
description	In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on–off” equilibrium of the thin filament state toward the “on” sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; viz., an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the “on–off” equilibrium of the thin filament state.
topic	actomyosin Ca2+ sensitivity cardiac muscle skeletal muscle temperature tropomyosin
url	https://www.frontiersin.org/article/10.3389/fphys.2020.00278/full
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Thermal Activation of Thin Filaments in Striated Muscle

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