Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

The non-selective mechanosensitive ion channel PIEZO1 controls erythrocyte volume homeostasis. Different missense gain-of-function mutations in PIEZO1 gene have been identified that cause Hereditary Xerocytosis (HX), a rare autosomal dominant haemolytic anemia. PIEZO1 expression is not limited to er...

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Bibliographic Details
Main Authors: Francesca Aglialoro, Naomi Hofsink, Menno Hofman, Nicole Brandhorst, Emile van den Akker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
PIEZO1
integrins
calcium signaling
integrin α4β1
erythroblastic island
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00958/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00958/full

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