ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB

ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB

Similar to all other positive-strand RNA viruses, enteroviruses reorganize host cellular membranes for efficient genome replication. A host lipid kinase, PI4KB, plays an important role in this membrane rearrangement. The exact mechanism of how enteroviruses recruit PI4KB was unclear. Here, we reveal...

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Bibliographic Details
Main Authors: Heyrhyoung Lyoo, Hilde M. van der Schaar, Cristina M. Dorobantu, Huib H. Rabouw, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
acyl-coenzyme A binding domain containing 3 (ACBD3)
phosphatidylinositol 4-kinase IIIβ (PI4KB)
enterovirus
replication organelles
viral replication
virus-host interactions
Online Access:https://doi.org/10.1128/mBio.02742-18

Internet

https://doi.org/10.1128/mBio.02742-18

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