MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer

MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer

Abstract Background Chemo-resistance is one of the major challenges in the therapy of small cell lung cancer (SCLC). Multiple mechanisms are thought to be involved in chemo-resistance during SCLC treatment, but unfortunately, these mechanisms have not been well elucidated. Herein, we investigated th...

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Bibliographic Details
Main Authors: Jinzhi Lai, Hainan Yang, Yanyang Zhu, Mei Ruan, Yayu Huang, Qiuyu Zhang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Small cell lung cancer
MiR-7-5p
Chemo-resistance
Doxorubicin
Poly ADP-ribose polymerase 1
Homologous recombination
Online Access:http://link.springer.com/article/10.1186/s12885-019-5798-7

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http://link.springer.com/article/10.1186/s12885-019-5798-7

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