SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential

SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential

Background: Metabolic reprogramming plays an essential role on lymphoma progression. Dysregulation of glutamine metabolism is implicated in natural-killer T-cell lymphoma (NKTCL) and tumor cell response to asparaginase-based anti-metabolic treatment. Methods: To understand the metabolomic alteration...

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Bibliographic Details
Main Authors: Jie Xiong, Nan Wang, Hui-Juan Zhong, Bo-Wen Cui, Shu Cheng, Rui Sun, Jia-Yi Chen, Peng-Peng Xu, Gang Cai, Li Wang, Xiao-Jian Sun, Jin-Yan Huang, Wei-Li Zhao
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:EBioMedicine
Subjects:
Natural-killer T-cell lymphoma
Solute carrier family 1 member 1
EAAT3
Metabolomics
RNA-sequencing
Glutamine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004072

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http://www.sciencedirect.com/science/article/pii/S2352396421004072

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