Ring-like oligomers of Synaptotagmins and related C2 domain proteins

Ring-like oligomers of Synaptotagmins and related C2 domain proteins

We recently reported that the C2AB portion of Synaptotagmin 1 (Syt1) could self-assemble into Ca2+-sensitive ring-like oligomers on membranes, which could potentially regulate neurotransmitter release. Here we report that analogous ring-like oligomers assemble from the C2AB domains of other Syt isof...

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Bibliographic Details
Main Authors: Maria N Zanetti, Oscar D Bello, Jing Wang, Jeff Coleman, Yiying Cai, Charles V Sindelar, James E Rothman, Shyam S Krishnakumar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
neurotransmitters
membrane fusion
electron microscopy
Online Access:https://elifesciences.org/articles/17262

Internet

https://elifesciences.org/articles/17262

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