Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present report describes functional and structural analys...

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Bibliographic Details
Main Authors: Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, David N Furness, Alexander F J van Aken, Walter Marcotti, Corné J Kros, Guy P Richardson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3080917?pdf=render

Internet

http://europepmc.org/articles/PMC3080917?pdf=render

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