Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till...

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Bibliographic Details
Main Authors: Arnaud F. Kouam, Fei Yuan, Frédéric N. Njayou, Hongtao He, Roméo F. Tsayem, Babayemi O. Oladejo, Fuhang Song, Paul F. Moundipa, George F. Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
K. grandifoliola
limonoids
acetaminophen
hepatoprotection
Mkp-1
Nrf2
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00653/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00653/full

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