Comparative Analysis of Clinical and Environmental Strains of Exophiala spinifera by Long-Reads Sequencing and RNAseq Reveal Adaptive Strategies

Comparative Analysis of Clinical and Environmental Strains of Exophiala spinifera by Long-Reads Sequencing and RNAseq Reveal Adaptive Strategies

Exophiala spinifera, a capsule-producing black yeast, is overrepresented as agent of disseminated infection in humans with inherited dysfunction of the CARD9 gene. In a review of published caspase recruitment domain-containing protein 9 (CARD9) deficiency cases, black fungi were linked to mutations...

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Bibliographic Details
Main Authors: Yinggai Song, Minghao Du, Nickolas Menezes da Silva, Ence Yang, Vania A. Vicente, G. Sybren de Hoog, Ruoyu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
black yeasts
comparative genomics
transcriptome analysis
intraspecific variability
gene rearrangement
CARD9 deficiency
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01880/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01880/full

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