Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster

Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster

Recently, activating mutations of the hypoxia-inducible factor 2α gene (HIF2A/EPAS1) have been recognized to predispose to multiple paragangliomas (PGLs) and duodenal somatostatinomas associated with polycythemia, and ocular abnormalities. Previously, mutations in the SDHA/B/C/D, SDHAF2, VHL, FH, PH...

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Bibliographic Details
Main Authors: Stephanie M.J. Fliedner, Uma Shankavaram, Geena Marzouca, Abdel Elkahloun, Ivana Jochmanova, Roland Daerr, W. Marston Linehan, Henri Timmers, Arthur S. Tischler, Konstantinos Papaspyrou, Jürgen Brieger, Ronald de Krijger, Jan Breza, Graeme Eisenhofer, Zhengping Zhuang, Hendrik Lehnert, Karel Pacak
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616300239

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http://www.sciencedirect.com/science/article/pii/S1476558616300239

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