Predisposition to Alzheimer’s and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel

Predisposition to Alzheimer’s and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel

Accumulating epidemiological evidence supports that chronic exposure to ambient fine particular matters of <2.5 μm (PM2.5) predisposes both children and adults to Alzheimer’s disease (AD) and age-related brain damage leading to dementia. There is also experimental evidence to show that PM2.5...

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Bibliographic Details
Main Authors: Lu Wang, Lin Yu Wei, Ran Ding, Yanyan Feng, Dongliang Li, Chaokun Li, Philippa Malko, Sharifah A. Syed Mortadza, Weidong Wu, Yaling Yin, Lin-Hua Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
Alzheimer’s disease
age-related brain pathologies
PM2.5
oxidative stress
TRPM2 channel
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00155/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00155/full

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