Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide. Yet potential differences in the biology of DNA damage induction a...

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Bibliographic Details
Main Authors: Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
ionizing radiation
DNA damage foci
DNA repair
spread-out Bragg peak (SOBP)
relative biological effectiveness (RBE)
entrance plateau (EP) protons
Online Access:https://www.mdpi.com/2073-4409/9/4/889

Internet

https://www.mdpi.com/2073-4409/9/4/889

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