Nucleolin Targeting by N6L Inhibits Wnt/β-Catenin Pathway Activation in Pancreatic Ductal Adenocarcinoma

Nucleolin Targeting by N6L Inhibits Wnt/β-Catenin Pathway Activation in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and resistant cancer with no available effective therapy. We have previously demonstrated that nucleolin targeting by N6L impairs tumor growth and normalizes tumor vessels in PDAC mouse models. Here, we investigated new pathways that are...

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Bibliographic Details
Main Authors: Fabio Raineri, Sandrine Bourgoin-Voillard, Mélissande Cossutta, Damien Habert, Matteo Ponzo, Claire Houppe, Benoît Vallée, Michele Boniotto, Mounira Chalabi-Dchar, Philippe Bouvet, Anne Couvelard, Jerome Cros, Anais Debesset, José L. Cohen, José Courty, Ilaria Cascone
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
nucleolin
N6L
Wnt/β-catenin pathway
tumor microenvironment
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/13/12/2986

Internet

https://www.mdpi.com/2072-6694/13/12/2986

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