Knockout of Toll-Like Receptors 2 and 4 Prevents Renal Ischemia-Reperfusion-Induced Cardiac Hypertrophy in Mice.

Knockout of Toll-Like Receptors 2 and 4 Prevents Renal Ischemia-Reperfusion-Induced Cardiac Hypertrophy in Mice.

We investigated whether the pathways linked to Toll-like receptors 2 and 4 (TLRs) are involved in renal ischemia-reperfusion (I/R)-induced cardiac hypertrophy. Wild type (WT) C57BL/6J, TLR2-/- and TLR4-/- mice were subjected to left kidney ischemia for 60 min followed by reperfusion for 5, 8, 12 and...

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Main Authors: Mayra Trentin-Sonoda, Rogério Cirino da Silva, Fernanda Vieira Kmit, Mariana Vieira Abrahão, Gustavo Monnerat Cahli, Guilherme Visconde Brasil, Humberto Muzi-Filho, Paulo André Silva, Fernanda Freire Tovar-Moll, Adalberto Vieyra, Emiliano Medei, Marcela Sorelli Carneiro-Ramos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0139350

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https://doi.org/10.1371/journal.pone.0139350

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