The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models

The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models

Particular interest to harness the innate immune system for cancer immunotherapy is fueled by limitations of immune checkpoint blockade. Plasmacytoid dendritic cells (pDC) are detected in a variety of solid tumors and correlate with poor clinical outcome. Release of type I interferons in response to...

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Bibliographic Details
Main Authors: Ilona-Petra Maser, Sabine Hoves, Christa Bayer, Gordon Heidkamp, Falk Nimmerjahn, Jan Eckmann, Carola H. Ries
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
humanized mice
myeloid-enhanced mice
plasmacytoid dendritic cells (pDC)
cancer immunotherapy
human pDC targeting
TLR agonists
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02082/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02082/full

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