M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function. Secretion of TGFβ and upregulation of immune checkpoint programmed cell death ligand-1 (PD-L1) are two main contributors to immune evasion...

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Bibliographic Details
Main Authors: Karin M. Knudson, Kristin C. Hicks, Xiaoling Luo, Jin-Qiu Chen, Jeffrey Schlom, Sofia R. Gameiro
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
pd-l1
tgfβ
carcinoma
checkpoint blockade
tumor microenvironment
twist1
vaccine
adenovirus
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1426519

Internet

http://dx.doi.org/10.1080/2162402X.2018.1426519

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