Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats

Neonatal hyperglycemia induces CXCL10/CXCR3 signaling and microglial activation and impairs long-term synaptogenesis in the hippocampus and alters behavior in rats

Abstract Background Hyperglycemia is common in extremely low gestational age newborns (ELGAN) and is associated with increased mortality and morbidity, including abnormal neurodevelopment. Hippocampus-mediated cognitive deficits are common in this population, but the specific effects of hyperglycemi...

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Bibliographic Details
Main Authors: Katherine M. Satrom, Kathleen Ennis, Brian M. Sweis, Tatyana M. Matveeva, Jun Chen, Leif Hanson, Akhil Maheshwari, Raghavendra Rao
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
Prematurity
Blood glucose
Inflammation
Oxidative stress
Neurodevelopment
Hyperglycemia
Online Access:http://link.springer.com/article/10.1186/s12974-018-1121-9

Internet

http://link.springer.com/article/10.1186/s12974-018-1121-9

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