Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment

Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment

The identification of novel pan-sigma receptor (SR) modulators, potentially useful in cancer treatment, represents a new goal of our research. Here, we report on the preparation of novel chiral compounds characterized by a 3-C alkyl chain bridging an aromatic portion to a 4-benzyl-piperidine moiety....

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Bibliographic Details
Main Authors: Marta Rui, Annamaria Marra, Vittorio Pace, Markus Juza, Daniela Rossi, Simona Collina
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
sigma receptor (SR) modulators
amylose- and cellulose-derived CSPs
chiral resolution
enantioselective HPLC
electronic circular dichroism (ECD)
Online Access:http://www.mdpi.com/1420-3049/21/9/1210

Internet

http://www.mdpi.com/1420-3049/21/9/1210

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