Human mutations in integrator complex subunits link transcriptome integrity to brain development.
Integrator is an RNA polymerase II (RNAPII)-associated complex that was recently identified to have a broad role in both RNA processing and transcription regulation. Importantly, its role in human development and disease is so far largely unexplored. Here, we provide evidence that biallelic Integrat...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-05-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5466333?pdf=render |