In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma

In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma

Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) could potentially provide unlimited HSCs for clinical transplantation, a curative treatment for numerous blood diseases. However, to date, bona fide HSC generation has been largely unsuccessful in vitro. We have previou...

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Bibliographic Details
Main Authors: Masao Tsukada, Yasunori Ota, Adam C. Wilkinson, Hans J. Becker, Motomi Osato, Hiromitsu Nakauchi, Satoshi Yamazaki
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
hematopoietic stem cell
induced pluripotent stem cell
teratomas
hemogenic endothelium
Gfi1b
cFos
Gata2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303673

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http://www.sciencedirect.com/science/article/pii/S2213671117303673

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