PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

Abstract Poor trastuzumab (Tmab) response of patients with human epidermal growth factor receptor 2-overexpressing gastric or gastroesophageal junction adenocarcinoma (HER2-GEA) is associated with the inhibition of phosphatase and tensin homolog (PTEN) expression. In this multicenter, retrospective...

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Bibliographic Details
Main Authors: Daiju Yokoyama, Shigeo Hisamori, Yasunori Deguchi, Tatsuto Nishigori, Hiroshi Okabe, Seiichiro Kanaya, Dai Manaka, Yoshio Kadokawa, Hiroaki Hata, Sachiko Minamiguchi, Shigeru Tsunoda, Kazutaka Obama, Yoshiharu Sakai
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88331-3

Internet

https://doi.org/10.1038/s41598-021-88331-3

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