Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

Summary: A major pathway for proinflammatory protein release by macrophages is inflammasome-mediated pyroptotic cell death. As conventional secretion, unconventional secretion, and cell death are executed simultaneously, however, the cellular mechanisms regulating this complex paracrine program rema...

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Bibliographic Details
Main Authors: Kshiti Phulphagar, Lars I. Kühn, Stefan Ebner, Annika Frauenstein, Jonathan J. Swietlik, Jan Rieckmann, Felix Meissner
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
pyroptosis
gasdermin D
macrophage
protein secretion
secretome
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001406

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http://www.sciencedirect.com/science/article/pii/S2211124721001406

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