Adeno-Associated Virus (AAV) Versus Immune Response

Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including tissue targeting, delivery across the blood⁻brain barrier (BBB), and host immune responses. These issues remain pertinent till today. Since then, several advances have been made in elucidating structur...

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Bibliographic Details
Main Authors: Joseph Rabinowitz, Ying Kai Chan, Richard Jude Samulski
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/11/2/102