Adeno-Associated Virus (AAV) Versus Immune Response

Adeno-Associated Virus (AAV) Versus Immune Response

Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including tissue targeting, delivery across the blood⁻brain barrier (BBB), and host immune responses. These issues remain pertinent till today. Since then, several advances have been made in elucidating structur...

Full description

Bibliographic Details
Main Authors:	Joseph Rabinowitz, Ying Kai Chan, Richard Jude Samulski
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Viruses
Subjects:	rAAV immune response rare diseases
Online Access:	https://www.mdpi.com/1999-4915/11/2/102

Similar Items

Monobac System–A Single Baculovirus for the Production of rAAV
by: Lionel Galibert, et al.
Published: (2021-08-01)

Evaluation of gene transfer strategies using recombinant adeno-associated viruses for Parkinson’s disease cell and gene therapy/Evaluation de stratégies de transfert de gènes via les virus adéno-associés recombinants pour la thérapie génique et cellulaire de la maladie de Parkinson
by: Bockstael, Olivier
Published: (2010)

Adeno-Associated Virus Mediated Gene Therapy for Corneal Diseases
by: Prabhakar Bastola, et al.
Published: (2020-08-01)

Preclinical Assessment of Immune Responses to AAV (adeno-associated virus) Vectors
by: Etiena eBasner-Tschakarjan, et al.
Published: (2014-02-01)

Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia
by: Marie Reine Haddad, et al.
Published: (2013-01-01)

Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing
by: Emilie Lecomte, et al.
Published: (2015-01-01)

A qPCR Method for AAV Genome Titer with ddPCR-Level of Accuracy and Precision
by: Yu Wang, et al.
Published: (2020-12-01)

All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo
by: Raed Ibraheim, et al.
Published: (2018-09-01)

Diverse Effects of DNA Repair Pathways on the Outcome of Recombinant Adeno-Associated Virus (rAAV) Vector Gene Delivery
by: Cataldi, Marcela Patricia
Published: (2011)

Recombinant Adeno-associated Viral Vector Design Influences Genotoxic Potential
by: Westmoreland, Patrick Riley
Published: (2018)

Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells
by: Xuefeng Deng, et al.
Published: (2020-04-01)

Quantitative analysis of genome packaging in recombinant AAV vectors by charge detection mass spectrometry
by: Lauren F. Barnes, et al.
Published: (2021-12-01)

Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy
by: Yeon-Suk Yang, et al.
Published: (2020-06-01)

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids
by: Helena Meyer-Berg, et al.
Published: (2020-10-01)

Prevention and inhibition of adverse humoral immune response to gene therapy mediated by adeno-associated virus (AAV) vector
by: Meliani, Amine
Published: (2018)

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
by: Stephanie Morscheid, et al.
Published: (2019-05-01)

Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo
by: Qingyun Zheng, et al.
Published: (2021-09-01)

Alternative Anesthesia of Neonatal Mice for Global rAAV Delivery in the Brain With Non-detectable Behavioral Interference in Adults
by: Wannan Tang, et al.
Published: (2020-07-01)

Characterization of Recombinant Adeno-Associated Viruses (rAAVs) for Gene Therapy Using Orthogonal Techniques
by: Liam Cole, et al.
Published: (2021-04-01)

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model
by: Rey-Rico A, et al.
Published: (2017-09-01)

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors
by: Ruth Rieser, et al.
Published: (2021-05-01)

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
by: Fernando Alvarez-Rivera, et al.
Published: (2020-04-01)

Comparative Analysis of Gene Transfer to Human and Rat Retinal Pigment Epithelium Cell Line by a Combinatorial Use of Recombinant Adeno- Associated Virus and Ultrasound or/and Microbubbles
by: Xiao-Zhi Zheng, et al.
Published: (2009-08-01)

Creation of a High-Yield AAV Vector Production Platform in Suspension Cells Using a Design-of-Experiment Approach
by: Huiren Zhao, et al.
Published: (2020-09-01)

Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High Fat Diets
by: Laurence B Lindenmaier, et al.
Published: (2016-08-01)

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells
by: Stephanie Morscheid, et al.
Published: (2019-08-01)

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
by: Jagadeesh K. Venkatesan, et al.
Published: (2018-09-01)

Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors
by: Gai Ran, et al.
Published: (2020-06-01)

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors
by: Giuseppe Ronzitti, et al.
Published: (2020-04-01)

A Versatile Method for Viral Transfection of Calcium Indicators in the Neonatal Mouse Brain
by: Cynthia X. He, et al.
Published: (2018-07-01)

Causal interrogation of neuronal networks and behavior through virally transduced ivermectin receptors
by: Horst Andreas Obenhaus, et al.
Published: (2016-08-01)

Establishment of Recombinant Adeno-Associated Virus Vector Integration Frequency In Vitro and In Vivo
by: Odeh, Mona
Published: (2012)

<i>Bombyx mori</i> Pupae Efficiently Produce Recombinant AAV2/HBoV1 Vectors with a <i>Bombyx mori</i> Nuclear Polyhedrosis Virus Expression System
by: Qian Yu, et al.
Published: (2021-04-01)

Therapeutic Delivery of rAAV <i>sox9</i> via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
by: Jonas Urich, et al.
Published: (2020-06-01)

Recombinant Adeno-Associated Virus-Mediated Delivery of MicroRNA-21-3p Lowers Hypertension
by: Feng Wang, et al.
Published: (2018-06-01)

HIV-1/SIV Neutralizing Antibody Gene Delivery: A Novel Vaccination Approach
by: Zhang, Jian Chao
Published: (2009)

Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo
by: Eileen M. Denovan-Wright, et al.
Published: (2008-03-01)

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
by: Edward E. Large, et al.
Published: (2021-07-01)

Humoral immune response to AAV
by: Roberto eCalcedo, et al.
Published: (2013-10-01)

Adeno-associated viral vectors at the frontier between tolerance and immunity
by: Federico eMingozzi, et al.
Published: (2015-03-01)

Cannot write session to /tmp/vufind_sessions/sess_57ga6f6dn66vgmfesi4g6njs0v