Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells.

Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells.

4-Hydroxy-2-hexenal (HHE), the aldehyde product of lipid peroxidation, may be responsible for the pathogenesis of progressive renal disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to be renoprotective through its anti-inflammatory and antifibrotic effects in various exper...

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Bibliographic Details
Main Authors: Chang Seong Kim, Soo Yeon Joo, Ko Eun Lee, Joon Seok Choi, Eun Hui Bae, Seong Kwon Ma, Suhn Hee Kim, Jongun Lee, Soo Wan Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3656901?pdf=render

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http://europepmc.org/articles/PMC3656901?pdf=render

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