RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

Abstract Background Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising targets in the therapy of advanced non-small cell lung cancer (NSCLC) and are predominantly detected by immunohistochemistry (IHC) and/or fluorescence in-situ hybridization (FISH). However, both method...

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Bibliographic Details
Main Authors: Claudia Vollbrecht, Dido Lenze, Michael Hummel, Annika Lehmann, Markus Moebs, Nikolaj Frost, Philipp Jurmeister, Leonille Schweizer, Udo Kellner, Manfred Dietel, Maximilian von Laffert
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer (NSCLC)
Anaplastic lymphoma kinase (ALK)
Fluorescence in-situ hybridization (FISH)
Immunohistochemistry (IHC)
Massive parallel sequencing (MPS)
NanoString
Online Access:http://link.springer.com/article/10.1186/s12885-018-5070-6

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http://link.springer.com/article/10.1186/s12885-018-5070-6

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