Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epi...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04989-w |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium |
| spellingShingle |
Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma Nature Communications |
| author_facet |
Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium |
| author_sort |
Molly Went |
| title |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| title_short |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| title_full |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| title_fullStr |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| title_full_unstemmed |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| title_sort |
identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-09-01 |
| description |
Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility. |
| url |
https://doi.org/10.1038/s41467-018-04989-w |
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1721449914342309888 |
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doaj-af73d8d01835421aac1fd29b48af60932021-05-11T09:25:31ZengNature Publishing GroupNature Communications2041-17232018-09-019111010.1038/s41467-018-04989-wIdentification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myelomaMolly Went0Amit Sud1Asta Försti2Britt-Marie Halvarsson3Niels Weinhold4Scott Kimber5Mark van Duin6Gudmar Thorleifsson7Amy Holroyd8David C. Johnson9Ni Li10Giulia Orlando11Philip J. Law12Mina Ali13Bowang Chen14Jonathan S. Mitchell15Daniel F. Gudbjartsson16Rowan Kuiper17Owen W. Stephens18Uta Bertsch19Peter Broderick20Chiara Campo21Obul R Bandapalli22Hermann Einsele23Walter A. Gregory24Urban Gullberg25Jens Hillengass26Per Hoffmann27Graham H. Jackson28Karl-Heinz Jöckel29Ellinor Johnsson30Sigurður Y. Kristinsson31Ulf-Henrik Mellqvist32Hareth Nahi33Douglas Easton34Paul Pharoah35Alison Dunning36Julian Peto37Federico Canzian38Anthony Swerdlow39Rosalind A. Eeles40ZSofia Kote-Jarai41Kenneth Muir42Nora Pashayan43Jolanta Nickel44Markus M. Nöthen45Thorunn Rafnar46Fiona M. Ross47Miguel Inacio da Silva Filho48Hauke Thomsen49Ingemar Turesson50Annette Vangsted51Niels Frost Andersen52Anders Waage53Brian A. Walker54Anna-Karin Wihlborg55Annemiek Broyl56Faith E. Davies57Unnur Thorsteinsdottir58Christian Langer59Markus Hansson60Hartmut Goldschmidt61Martin Kaiser62Pieter Sonneveld63Kari Stefansson64Gareth J. Morgan65Kari Hemminki66Björn Nilsson67Richard S. Houlston68The PRACTICAL consortiumDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchGerman Cancer Research CenterHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityMyeloma Institute for Research and Therapy, University of Arkansas for Medical SciencesDivision of Molecular Pathology, The Institute of Cancer ResearchDepartment of Hematology, Erasmus MC Cancer InstitutedeCODE GeneticsDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Molecular Pathology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityGerman Cancer Research CenterDivision of Genetics and Epidemiology, The Institute of Cancer ResearchdeCODE GeneticsDepartment of Hematology, Erasmus MC Cancer InstituteMyeloma Institute for Research and Therapy, University of Arkansas for Medical SciencesGerman Cancer Research CenterDivision of Genetics and Epidemiology, The Institute of Cancer ResearchGerman Cancer Research CenterGerman Cancer Research CenterUniversity Clinic of WürzburgClinical Trials Research Unit, University of LeedsHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityDepartment of Internal Medicine V, University of HeidelbergInstitute of Human Genetics, University of BonnRoyal Victoria InfirmaryInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg–EssenHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityDepartment of Hematology, Landspitali, National University Hospital of IcelandSection of Hematology, Sahlgrenska University HospitalCenter for Hematology and Regenerative MedicineCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical MedicineGenomic Epidemiology Group, German Cancer Research Center (DKFZ)Division of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchInstitute of Population Health, University of ManchesterCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeDepartment of Internal Medicine V, University of HeidelbergInstitute of Human Genetics, University of BonndeCODE GeneticsWessex Regional Genetics Laboratory, University of SouthamptonGerman Cancer Research CenterGerman Cancer Research CenterHematology Clinic, Skåne University HospitalDepartment of Haematology, University Hospital of Copenhagen at RigshospitaletDepartment of Haematology, Aarhus University HospitalDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and TechnologyMyeloma Institute for Research and Therapy, University of Arkansas for Medical SciencesHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityDepartment of Hematology, Erasmus MC Cancer InstituteMyeloma Institute for Research and Therapy, University of Arkansas for Medical SciencesdeCODE GeneticsDepartment of Internal Medicine III, University of UlmHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityDepartment of Internal Medicine V, University of HeidelbergDivision of Molecular Pathology, The Institute of Cancer ResearchDepartment of Hematology, Erasmus MC Cancer InstitutedeCODE GeneticsMyeloma Institute for Research and Therapy, University of Arkansas for Medical SciencesGerman Cancer Research CenterHematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, Lund UniversityDivision of Genetics and Epidemiology, The Institute of Cancer ResearchMultiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.https://doi.org/10.1038/s41467-018-04989-w |