Multiple Skin Squamous Cell Carcinomas in Junctional Epidermolysis Bullosa Due to Altered Laminin-332 Function

Multiple Skin Squamous Cell Carcinomas in Junctional Epidermolysis Bullosa Due to Altered Laminin-332 Function

Variably reduced expression of the basement membrane component laminin-332 (α3aβ3γ2) causes junctional epidermolysis bullosa generalized intermediate (JEB-GI), a skin fragility disorder with an increased susceptibility to squamous cell carcinoma (SCC) development in adulth...

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Bibliographic Details
Main Authors: Paola Fortugno, Angelo Giuseppe Condorelli, Elena Dellambra, Liliana Guerra, Francesca Cianfarani, Lavinia Tinaburri, Vittoria Proto, Naomi De Luca, Francesca Passarelli, Francesca Ricci, Giovanna Zambruno, Daniele Castiglia
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
lamb3
disulphide bond
laminin assembly
laminin coiled-coil domain
epidermal carcinogenesis
extracellular matrix
Online Access:https://www.mdpi.com/1422-0067/21/4/1426

Internet

https://www.mdpi.com/1422-0067/21/4/1426

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