Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis

Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis

Prolyl 3-hydroxylase 2 (P3H2) catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Its activity has never been directly associated to angiogenesis. Here, we identified P3H2 gene through a deep-sequencing transcriptome analysis of human umbilical vein endoth...

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Bibliographic Details
Main Authors: Paola Pignata, Ivana Apicella, Valeria Cicatiello, Caterina Puglisi, Sara Magliacane Magliacane Trotta, Remo Sanges, Valeria Tarallo, Sandro De De Falco
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
angiogenesis
Prolyl 3-hydroxylase 2
Collagen IV
vascular endothelial growth factor A
choroidal neovascularization
age-related macular degeneration
Online Access:https://www.mdpi.com/1422-0067/22/8/3896

Internet

https://www.mdpi.com/1422-0067/22/8/3896

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