A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors

A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors

Recombinant adeno-associated viral (rAAV) vectors have been widely used in human gene therapy. One major impediment to its broad application is the inability to produce high-quality vectors in mass quantity. Here, an efficient and scalable suspension cell culture system for the production of rAAV ve...

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Bibliographic Details
Main Authors: Qizhao Wang, Zhongren Wu, Junping Zhang, Jenni Firrman, Hongying Wei, Zhengjing Zhuang, LinShu Liu, Linqing Miao, Yang Hu, Dong Li, Yong Diao, Weidong Xiao
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
vaccinia virus
VP1
gene therapy
vector production
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301183

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http://www.sciencedirect.com/science/article/pii/S2329050117301183

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