TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.

BACKGROUND: The TGF family plays a key role in bone homeostasis. Systemic or topic application of proteins of this family apparently positively affects bone healing in vivo. However, patients with chronic inflammation, having increased TGF-β(1) serum-levels, often show reduced bone mineral content a...

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Bibliographic Details
Main Authors: Sabrina Ehnert, Johannes Baur, Andreas Schmitt, Markus Neumaier, Martin Lucke, Steven Dooley, Helen Vester, Britt Wildemann, Ulrich Stöckle, Andreas K Nussler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2989906?pdf=render