Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways

Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways

Abstract Background Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects the effect of metformin, especially low glucose in the culture medium can enhance the cytotoxicity of metformin on cancer cells. Since mitochond...

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Bibliographic Details
Main Authors: Liwei Ma, Jianwei Wei, Junhu Wan, Weiwei Wang, Li Wang, Yongjie Yuan, Zijun Yang, Xianzhi Liu, Liang Ming
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mitochondrial damage
ER stress
ASK1
Metformin
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1090-6

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http://link.springer.com/article/10.1186/s13046-019-1090-6

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