Immunotherapy with 4-1BBL-Expressing iPS Cell‐Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma

Immunotherapy with 4-1BBL-Expressing iPS Cell‐Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma

We have established an immune cell therapy with immortalized induced pluripotent stem-cell–derived myeloid lines (iPS-ML). The benefits of using iPS-ML are the infinite proliferative capacity and ease of genetic modification. In this study, we introduced 4-1BBL gene to iPS-ML (iPS-ML-41BBL). The ana...

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Bibliographic Details
Main Authors: Haruka Kuriyama, Satoshi Fukushima, Toshihiro Kimura, Hisashi Kanemaru, Azusa Miyashita, Etsuko Okada, Yosuke Kubo, Satoshi Nakahara, Aki Tokuzumi, Yuki Nishimura, Ikko Kajihara, Katsunari Makino, Jun Aoi, Shinichi Masuguchi, Hirotake Tsukamoto, Takashi Inozume, Rong Zhang, Tetsuya Nakatsura, Yasushi Uemura, Satoru Senju, Hironobu Ihn
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
iPS cells
4-1BBL
CXCR6
melanoma
immune cell therapy
Online Access:https://www.mdpi.com/1422-0067/22/4/1958

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https://www.mdpi.com/1422-0067/22/4/1958

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