Pre-plaque Aß-Mediated Impairment of Synaptic Depotentiation in a Transgenic Rat Model of Alzheimer’s Disease Amyloidosis

Pre-plaque Aß-Mediated Impairment of Synaptic Depotentiation in a Transgenic Rat Model of Alzheimer’s Disease Amyloidosis

How endogenously produced soluble amyloid ß-protein (Aß) affects synaptic plasticity in vulnerable circuits should provide insight into early Alzheimer’s disease pathophysiology. McGill-R-Thy1-APP transgenic rats, modeling Alzheimer’s disease amyloidosis, exhibit an age-dependent soluble Aß-mediated...

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Bibliographic Details
Main Authors: Yingjie Qi, Igor Klyubin, Neng-Wei Hu, Tomas Ondrejcak, Michael J. Rowan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Neuroscience
Subjects:
soluble amyloid beta
synaptic plasticity
hippocampus
novelty exploration
depotentiation
apical dendrites
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00861/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00861/full

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