A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of HGPS cells and improves survival of Zmpste24-de...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/63284 |