A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of HGPS cells and improves survival of Zmpste24-de...

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Bibliographic Details
Main Authors: Xue Chen, Haidong Yao, Muhammad Kashif, Gwladys Revêchon, Maria Eriksson, Jianjiang Hu, Ting Wang, Yiran Liu, Elin Tüksammel, Staffan Strömblad, Ian M Ahearn, Mark R Philips, Clotilde Wiel, Mohamed X Ibrahim, Martin O Bergo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
progeria
HGPS
senescence
ICMT
methylation
inhibitor
Online Access:https://elifesciences.org/articles/63284

Internet

https://elifesciences.org/articles/63284

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